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KMID : 0043319950180010027
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Archives of Pharmacal Research
1995 Volume.18 No. 1 p.27 ~ p.30
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Synthesis of Some Pyridine and Dihydropyridine Derivatives from 7-Hydroxy-8-Methoxyl-2-Oxo-2H-1-Benzopyran-6-Carboxaldehyde
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El-Diwani Hoda I.
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Abstract
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The Hantzsh reaction of 7-hydroxy-8-methoxy-2-oxo-2H-benzopyran-6-carboxaldehyde (1) with ethyl acetoacetate and ammonia yields the dihydropyridine derivative 2 together with the pyridine derivative 3 and the eight membred ring derivative 4. Reaction of 1 with ethyl cyanoacetate and malononitrile gives the iminodicoumarin derivatives 5 and 6 respectiely. The latter compound was reacted with butan-2-one and acetophenone to produce the Michael adduct 71, b and the 2-aminopyridine derivatives 8a, b.
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KEYWORD
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Hantzsh reaction, Coumarins, Benzopyrancarboxaldehyde, Dihydropyridine, Pyridines
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